Mental and brain illness are complex.

Symptoms overlap across conditions.

Polygenic and highly downstream.

Shaped by socio-economic environment.

So assessment must be dynamic —

built on multiple data streams,

continuously adapting as symptoms change.

We need it all — at one point.

That's why we built LifeBack®.

Translating precision in mental healthcare

Connected intelligence for brain and mental healthcare.

SIPL unifies clinical care, behavioural signals, neuroscience and genomics into one explainable AI system — learning from new data and adapting across populations.

GrantedIndian patent, PCT filed
91%HAM-D agreement, details
500+Hospital assessments
GCE-III₹50L+ equity-free fund support (BIRAC, DBT, BMGF)
Multi-siteClinical & institutional pilot partnerships
DPIITRecognised deep-tech startup
2018DBT–MoST Most Innovative Startup Award

About SIPL

Deep research, translated into clinical-grade AI.

Sequoia Insilico is a New Delhi-based BioAI company advancing mental and brain health. LifeBack®, our flagship, brings population-scale insight with individual precision at every stage of the treatment cycle—triage, point of care, prognosis, and risk assessment.

SIPL logo: Sequoia Insilico Private Limited
Measure. Monitor. Discover.

How SIPL works

One connected care continuum.

Care, Integration, and Discovery are connected capabilities in one clinical intelligence continuum — each informs the next and improves the whole loop.

Loop 01 · Care

Care

The clinical engine — assessment, scoring and monitoring clinicians use directly.

Assess · Stratify · Guide

Loop 02 · Integration

Integration

Built into hospital workflows and records, so it runs inside existing practice.

Integrate · Monitor

Loop 03 · Discovery

Discovery

New findings from R&D and patient outcomes, validated and folded back into care.

Discover

Working together as one loop

01 · Integration

Integrate

Bring in permitted data

02 · Care

Assess

Score clinical patterns

03 · Care

Stratify

Group by risk and response

04 · Care

Guide

Inform the clinician

05 · Integration

Monitor

Track change over time

06 · Discovery

Discover

Feed the next study

Every outcome from Discover flows back into Integrate — so the system keeps getting smarter.

Science

Proven before it reaches a patient.

Every model is a hypothesis until the evidence says otherwise — and we publish the limits alongside the results.

Validation

91%

agreement with clinician-rated HAM-D across 500+ assessments, validated with ABVIMS and Dr. RML Hospital, New Delhi.

Independent quality criteria

  • Evidence-based
  • Ethics
  • Data quality
  • Evaluation
  • External test

Recognition

  • ₹50L+

    Grand Challenges India (GCE-III)

    Equity-free award from BIRAC, DBT and the Bill & Melinda Gates Foundation.

  • Award

    Most Innovative Venture Award

    Awarded by the Department of Biotechnology (DBT), Government of India.

  • Patent

    Indian Patent No. 202511025669

    Published. WIPO PCT application in process.

  • DPIIT

    Recognised deep-science startup

    Government of India, Department for Promotion of Industry and Internal Trade.

Publications & talksResearch, reviews, conferences and events

BioAI for biopharma · Our horizon

The BioAI cornerstone for brain-health discovery.

The clinical intelligence we build for care today is laying the foundation for tomorrow's psychiatric research. These are the areas where SIPL and LifeBack® can help biopharma move faster — and where we're opening the conversation.

Stratification

Multilevel patient cohorts for enriched trials and better response outcomes.

Biomarkers

Potential clinically relevant biomarkers of disease state and treatment response, ready for prospective validation.

Pharmacogenomics In pipeline

Population-specific genetic markers of drug response and tolerability, starting with Indian cohorts.

Real-world evidence

Longitudinal outcomes from governed, consented clinical data.

Our precision framework

Precision has several dimensions.

Care is delivered to one patient — but it is only as precise as the foundations beneath it.

01

Diagnostic precision

What is really going on?

Reading overlapping disorders, comorbidities and trajectories together — not as isolated labels.

Comorbidity Differential diagnosis Trajectory

02

Population precision

Does it hold for this patient’s world?

Models built for the genetic, linguistic, cultural and socioeconomic reality they serve.

Genetics Language Culture

LifeBack®

Individual precision.

Multiple dimensions in one platform — so every insight translates into care made for one person.

LifeBack®

Built to deploy anywhere. Engineered for India first.

SIPL's flagship clinical-grade platform for brain and mental health — led by clinicians, not a self-serve app. Built with leading hospitals and clinical KOLs, it pairs demographically validated deep learning with patient-centred research and strong translational science.

  • B2B & B2B2C
  • White-label
  • Hospitals
  • Healthcare providers
  • Corporates
  • Institutions

Built for diversity

Adaptable globally.

  • Use-case–specific small language model for India's diverse population
  • SaaS, API-first — pilot in weeks, no IT change
  • Production-ready; integrates with existing HIS/EMR

Across the patient journey

Risk → diagnosis → response → prognosis → remission → relapse.

  • Clinical workflows, multimodal data and biological insight in one flow
  • Adaptive evaluation, clinician-led planning, long-term surveillance
  • Patient app links PROs to clinician dashboards between visits — relapse analytics for patients too

A collaboration platform

Backed by strong R&D and translational research.

  • Hospitals, research institutions and biopharma in brain, mental health and precision medicine
  • Co-creation, joint publications, co-hosted conferences, patent partnerships
  • Licensing complementary IP to strengthen services like Data-as-a-Service (DaaS)

Let's build the future of brain and mental healthcare together.

Tell us your focus — hospital, research, genomics, biopharma, or investment — and we’ll connect you with the right team.